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pentobarbital will reduce the level or effect of carvedilol by impacting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Watch.pentobarbital will lessen the extent or outcome of buprenorphine subdermal implant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Monitor patients now on buprenorphine subdermal i